Women's Health · Hormones
Menstrual cycle and hormones: why they become dysregulated and how to support your biology without blocking it
Menstrual pain, premenstrual syndrome, or irregular cycles are not "women's issues" that must be endured. They are signals that something in the hormonal balance can be improved. There is a huge difference between blocking the cycle and supporting it.
If you've ever wondered why some months you feel great and others you feel down for a week before your period, the answer lies in the hormonal dance that governs your cycle. And that dance can be fine-tuned.
At tres60, we start from a clear medical principle: the menstrual cycle is not a disease or an inconvenience. It is a highly sophisticated biological information system. When it generates intense symptoms — pain, extreme irritability, bloating, irregularities — it is signaling that something is out of calibration. And there are natural ways to help it return to balance.
The four phases of the cycle and what happens in each one
Understanding the cycle is the first step. It is not a linear 28-day process: it is a dynamic system with four phases with completely different hormonal profiles.
Menstrual
Days 1–5
Estrogen and progesterone at their lowest. High inflammation. Low energy.
Follicular
Days 6–13
Estrogen rising. Energy and mental clarity increasing. Productive phase.
Ovulatory
Days 14–16
Peak estrogen and testosterone. Maximum energy and vitality.
Luteal
Days 17–28
Progesterone high then falling. PMS, fluid retention, irritability.
Premenstrual syndrome (PMS) and dysmenorrhea (menstrual pain) are mainly concentrated in the luteal phase and the first days of the menstrual phase. Their intensity is not random: it depends on the balance between estrogen and progesterone, systemic inflammation levels, and nutritional status in key nutrients like magnesium or vitamin B6.
Why the cycle becomes dysregulated: factors nobody teaches us
Hormonal dysregulation has multiple and often cumulative causes. The most frequent in women of reproductive age are:
- Key nutrient deficiencies: magnesium, vitamin B6, zinc, and omega-3 fatty acids are direct cofactors in hormone synthesis and metabolism.
- Chronic stress: cortisol competes with progesterone for the same biochemical precursors. Prolonged stress suppresses the luteal phase and exacerbates PMS.
- Low-grade inflammation: amplifies the signal of prostaglandins, which are directly responsible for menstrual pain.
- Circadian rhythm disruption: the hypothalamic-pituitary-gonadal axis (which governs the cycle) is sensitive to sleep and light patterns.
- Exposure to endocrine disruptors: plastics, pesticides, certain cosmetics, and excess environmental estrogens alter the body's own hormonal balance.
Symptoms that indicate your cycle needs support
- Menstrual pain that interferes with your daily life (dysmenorrhea)
- Irritability, anxiety, or easy crying in the week before your period
- Abdominal bloating and cyclical fluid retention
- Irregular cycles (variations of more than 7 days from one month to another)
- Intermenstrual spotting or very heavy bleeding
- Intense fatigue on specific days of the cycle
- Intense cravings for sugar or carbohydrates in the luteal phase
- Premenstrual breast tenderness
- Sudden mood swings linked to the cycle
If several of these symptoms are common in your cycle, you are not experiencing something that you "just have to put up with." These are signs that the system can be regulated better.
CYKLO's medical philosophy
CYKLO does not block the cycle. It does not suppress hormones. It supports female biology by providing the nutrients and phytochemicals that help the body regulate its own cycles more efficiently. The difference between blocking and supporting is the difference between silencing an alarm and resolving what triggers it.
CYKLO's ingredients and why each one is included
Each component of CYKLO has a specific purpose and is supported by clinical evidence. None are included for cosmetic reasons.
Turmeric
100 mg standardized extract
First-line anti-inflammatory. Inhibits the COX-2 enzyme and reduces the production of inflammatory prostaglandins, directly responsible for menstrual pain.
Omega-3
200 mg (EPA + DHA)
Regulates the balance between pro- and anti-inflammatory prostaglandins. Clinical studies show a reduction in menstrual pain comparable to ibuprofen with continuous use.
Magnesium
100 mg bisglycinate
Relaxes uterine muscles, reduces cramps, and acts on the central nervous system by modulating premenstrual irritability and anxiety.
Vitex agnus-castus
20 mg extract
Acts on pituitary dopaminergic receptors, reducing prolactin and balancing the estrogen-progesterone ratio. The most studied phytochemical for PMS.
Ginger
100 mg extract
Natural antispasmodic. Inhibits the synthesis of prostaglandins and leukotrienes. Effective for dysmenorrhea and chronic pelvic inflammation.
Vitamin B6
10 mg
Essential cofactor in serotonin and dopamine synthesis. Reduces irritability, mood swings, and fatigue associated with PMS. Supports hormone synthesis in the liver.
Piperine
2.5 mg
Inhibits the hepatic metabolism of turmeric, increasing its bioavailability by up to 2,000%. Without piperine, much of the turmeric is eliminated before it can act.
Soy Extract
125 mg (isoflavones)
Phytoestrogens that gently modulate estrogen balance. Especially useful for perimenopausal women with early hormonal changes.
Who is CYKLO for?
Main profiles
- Women with moderate to intense PMS: irritability, bloating, recurrent mood swings in the luteal phase.
- Women with dysmenorrhea (menstrual pain that limits daily activity).
- Irregular cycles with no clear organic cause.
- Athletes who want to synchronize their training with cycle phases and experience fewer symptoms on menstruation days.
- Women in perimenopause with early hormonal changes (CYKLO for the active cycle; MenoHarmony for established menopause).
- Women with chronic pelvic pain or endometriosis (always with gynecological monitoring).
Combinations recommended by the medical team
CYKLO + LOGOUT — Balanced cycle and restful sleep
For women who not only experience physical symptoms but also difficulty sleeping and nocturnal anxiety during the luteal phase. LOGOUT provides melatonin, ashwagandha, and magnesium to regulate the nervous system at night, while CYKLO works on hormonal balance during the day.
CYKLO + REBOOT — Hormonal anti-inflammatory pack
Indicated for cases of persistent inflammation linked to the cycle: chronic pelvic pain, endometriosis, or very symptomatic cycles. REBOOT provides PEA, high-dose omega-3, and bacopa for neuroinflammation; CYKLO focuses on female hormonal balance.
How to take it and what to expect
2 capsules daily with breakfast or lunch, continuously. CYKLO is not taken only in certain phases of the cycle: it works on the hormonal system continuously, and its effects are cumulative.
The fastest changes —reduction of menstrual pain and bloating— are usually noticed in the first or second cycle. The effects on cycle regularity and long-term PMS reduction require three full cycles of continuous use to be accurately evaluated.
CYKLO — tres60
Natural hormone regulation. Formulated by medical specialists in sports medicine and women's health. Suitable for celiacs.
See CYKLO →Frequently asked questions about CYKLO
Can I take CYKLO if I am taking hormonal contraceptives?
Vitex agnus-castus may interact with medications affecting the dopaminergic axis or with the birth control pill. If you are taking hormonal contraceptives, consult your gynecologist before starting. The rest of the ingredients have no known interactions with hormonal contraception.
Is CYKLO the same as MenoHarmony?
No. CYKLO is formulated for women of reproductive age with an active cycle: PMS, dysmenorrhea, irregular cycles, and early perimenopausal changes. MenoHarmony is specifically designed for established menopause, with ingredients aimed at hot flashes, night sweats, and emotional stability during that stage. They are complementary products, not interchangeable.
How long does CYKLO take to take effect?
Anti-inflammatory effects (less pain, less bloating) can be noticed from the first cycle. Effects on cycle regularity and PMS reduction require at least 2-3 cycles of continuous use to be accurately assessed.
Can I take it if I am trying to conceive?
Vitex agnus-castus may influence ovulation. If you are actively trying to conceive, consult your gynecologist before taking CYKLO. It is not recommended during pregnancy.
This article is for informational purposes and has been written by the tres60 medical team. It does not replace the advice or diagnosis of a healthcare professional. Consult your gynecologist or doctor if you have questions about your cycle or are taking hormonal medication.
